Polyp subtype	Polyposis syndrome	Gene	Germline mutation found	Incidence	clinical criteria	CRC risk
Adenomatous	Familial adenomatous polyposis (FAP)	APC	70%-90%	1 in 10,000	Classic: > 100 adenomas in colon/rectum at age 25	100%
	Familial adenomatous polyposis (FAP)	APC	70%-90%	1 in 10,000	Attenuated: < 100 adenomas in colon/rectum at age 25	69%
	MUTYH-associated polypsis (MAP)	MUTYH	16%-40%	1-4 in 10,000	20-100 adenomas in colon/rectum	19%-43%
Hamartomatous	Peutz-Jeghers syndrome (PJS)	STK11/LKB1	80%-94%	1 in 250,000	1 ≥ 2 histologically confirmed Peutz-Jeghers polyps 2 any number of Peutz-Jeghers polyps in an individual with a positive family history of PJS 3 presence of characteristic mucocutaneous pigmentations in an individual with a positive family history of PJS 4 any number of Peutz-Jeghers polyps in an individual with characteristic mucocutaneous pigmentation	15%-57%
Hamartomatous	Juvenile polyposis syndrome (JPS)	SMAD4, BMPR1A	40%-60%	1-1.6 in 100,000	1 ≥ 5 juvenile polyps are present in the colon/rectum or in other parts of the gastrointestinal tract 2 any number of juvenile polyps in a patient with one or more relatives affected with JPS	39%-68%
Serrated	Serrated polyposis syndrome (SPS)	No germline mutation identified	NA	31-80 in 10,000 in FIT screening 42 in 10,000 in colonoscopy screening	1 ≥ 5 serrated polyps proximal to the sigmoid with ≥ 2 being > 10 mm 2 > 20 serrated polyps of any size distributed throughout the colon	15%-30%

Omitted

폴립증(polyposis)/폴립증후군(polyposis syndrome) 구독