50 mg/kg per day in 3 divided doses (maximum, 500 mg per dose)
macrolides
- azithromycin
500 mg/d(7–10일)
10 mg/kg/d(최대용량: 500 mg/dose)
Doxycycline
100mg bid
8세 미만에서는 추천되지 않음
8세 이상인 경우: 4 mg/kg/d, #2(최대용량: 100 mg/dose)
- clarithromycin
500 mg bid(14–21일, 임신중인 경우가 아닌 경우)
7.5 mg/kg bid (최대용량: 500 mg/dose)
Cefuroxime axetil
500mg bid
30 mg/kg/d, #2(최대용량: 500mg/dose)
- erythromycin
500 mg qid(14-21일)
12.5 mg/kg, qid(최대용량: 500 mg/dose)
정맥주사
Ceftriaxone
2 g/d, q24h, IV
50–75 mg/kg/d, q24h, IV (최대용량, 2 g)
Cefotaxime
2 g, iv, q8h
150–200 mg/kg/d, iv, #3-4(최대용량, 6 g/d)
Penicillin G
18–24millionU/d, iv, q4h
200,000–400,000 U/kg /d, q4h
(최대용량: < 18–24 millionU/d)
참고자료
대한감염학회. 감염학 개정판(2014). P701-708
DePietropaolo DL, Powers JH, Gill JM, Foy AJ. Diagnosis of lyme disease. Am Fam Physician 2005;72(2):297–304.
Government of Canada PHA of C. CCDR: Volume 40-11, May 29, 2014 - Public Health Agency of Canada [Internet]. 2014 [cited 2016 Dec 25];Available from: http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/14vol40/dr-rm40-11/index-eng.php
Moore A, Nelson C, Molins C, Mead P, Schriefer M. Current Guidelines, Common Clinical Pitfalls, and Future Directions for Laboratory Diagnosis of Lyme Disease, United States. Emerg Infect Dis 2016;22(7):1169–77.
Wormser GP, Dattwyler RJ, Shapiro ED, et al. The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 2006;43(9):1089–134.
